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Curated oncology headlines from reputable sources, ranked by importance with Claude Opus 4.7.
The versatile interplay between steatotic liver disease and liver cancer
A comprehensive review published in Nature Reviews Cancer examines how metabolic dysfunction-associated steatotic liver disease (MASLD) and alcoholic liver disease (ALD) drive the development of liver cancer through chronic liver injury and sustained inflammation. Rahbari and colleagues detail the distinct pathophysiological mechanisms by which each condition promotes hepatic carcinogenesis, highl…
TMEM87A suppresses ferroptosis and increases cancer immunotherapy resistance by maintaining the Golgi apparatus pH homeostasis
Researchers publishing in Nature Cancer have identified the protein TMEM87A as a key regulator of Golgi apparatus pH homeostasis that protects cancer cells from ferroptosis, a form of iron-dependent cell death driven by lipid peroxidation. The study by Li et al. demonstrates that TMEM87A counteracts ferroptosis-induced lipid peroxidation in the Golgi, and that its presence in tumors contributes to…