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Platinum chemotherapy ages the liver | Science
Platinum-based chemotherapy drugs induce somatic mutations and accelerate biological aging of the liver in children treated for cancer, according to a study published in Science. The findings reveal that cisplatin and related agents leave a lasting mutational footprint in hepatocytes, effectively making the organ biologically older than the patient's chronological age. The discovery has significan…
Male-biased Yap1-Cd276/B7-H3 axis for immune evasion in medulloblastoma
A study published in Cancer Cell by Abdelfattah and colleagues has identified a sex-biased mechanism of immune evasion in Sonic Hedgehog (SHH) medulloblastoma, revealing that male tumors preferentially rely on the YAP1 transcription co-activator to upregulate the immune checkpoint molecule CD276 (B7-H3). The research demonstrates that immune checkpoint molecules in medulloblastoma cancer cells are…