[Articles] Estimating total and diagnosed global cancer incidence and stage distribution from 1990 to 2050: a simulation-based analysis of 17 cancers

A comprehensive simulation-based study published in The Lancet Oncology has modeled both total and diagnosed cancer incidence across 17 cancer types worldwide from 1990 to 2050. The analysis reveals a substantial and growing global cancer burden, with particularly alarming gaps in low- and middle-income countries where many patients die without ever receiving a diagnosis. By integrating demographic trends, epidemiological shifts, and health system capacity factors, the modeling framework provides a tool for evaluating targeted interventions to strengthen oncology workforces and improve diagnostic pathways. The findings underscore the urgent need for investment in cancer detection infrastructure in resource-limited settings to reduce the hidden toll of undiagnosed cancers.