Identification of broadly tumour-reactive γδ TCRs from multiple myeloma

A machine-learning algorithm called PreGame identifies, in single-cell sequencing data, the γδ T cells that react to multiple myeloma cells, allowing their receptors to be isolated. Expansion of this cell population tracked with response to treatment, making it a candidate biomarker of therapeutic efficacy. The work appeared in Nature (2026) and is preclinical: the receptors described have not yet been tested as a treatment in patients.