Integrated clinicogenomic analysis reveals the evolution and metastatic tropisms of advanced colorectal cancer

An integrated clinicogenomic analysis of over 7,000 colorectal cancers combining next-generation sequencing with clinical data defined mutation clonality, dosage, and organ-specific metastatic tropisms linked to patient outcomes. The study mapped how genomic profiles of primary tumors—together with tumor sidedness and metastatic site—shape patterns of distant spread. Based on these findings, the authors developed an organ-specific risk model for metastasis that incorporates primary tumor location, genomics, and metastatic distribution.