Proximity-guided graph learning reveals tumour-associated proximity antigens

A proximity-mapping atlas of tumour cell surfaces has defined a new class of targets called tumour-associated proximity antigens — membrane proteins whose spatial co-localisation on cancer cells distinguishes them from healthy tissue. The study identified disease-associated membrane spatial communities and pinpointed the EGFR–CDCP1 pair as a co-target that enhances tumour killing when engaged simultaneously by multispecific therapeutics. The approach opens a systematic route to discovering combinatorial antigen pairs for next-generation bispecific and multispecific antibody design.