A bivalent molecular glue linking lysine acetyltransferases to oncogene-induced cell death

A novel bivalent molecular glue that induces proximity between lysine acetyltransferases (KATs) and the BCL6 oncoprotein reprograms epigenetic signaling to selectively kill lymphoma cells. Structural and mechanistic analyses revealed that fortuitous protein-protein contacts at the induced interface convert chemical proximity into targeted chromatin changes, driving malignant cell death. The work establishes a new mechanism by which small molecules can co-opt oncogenic transcriptional regulators, opening a potential therapeutic avenue for BCL6-dependent lymphomas.