Targeting angiogenesis: Lessons from 25 years of normalizing tumor vasculature

A major review published in Cell synthesizes 25 years of research on anti-angiogenic cancer therapy, tracing the field's evolution from the original concept of starving tumors by blocking blood vessel growth to the more nuanced strategy of vascular normalization. The authors highlight how spatial-omics technologies are providing unprecedented insights into the architecture and heterogeneity of tumor vasculature. The review also identifies emerging factors — neural signaling, the microbiome, hormonal regulation, and circadian biology — that influence tumor angiogenesis and may open new therapeutic avenues. While not reporting original experimental data, this comprehensive synthesis in a top-tier journal is expected to shape future research directions and combination treatment strategies across multiple solid tumor types.